In recent years, an increasing number of studies have been focusing on the impact of cannabis on adolescents, particularly the effects of THC, the main psychoactive component of cannabis, on the developing brain. It is known that THC in cannabis acts on the endocannabinoid receptors in the brain, among which the most important are the CB1 receptors, which are crucial for cognitive processes such as memory, attention, and executive functions. Unfortunately, the adolescent brain is still developing, and early cannabis use may cause lasting changes in the structure and function of the brain.

Thinning of the frontal cortex and its impact on cognitive abilities

The frontal cortex, the brain region responsible for decision-making, impulse control, and emotional regulation, is one of the last areas to mature in the human brain. According to numerous studies, adolescents who regularly use cannabis are exposed to a significant risk of thinning this brain region. Thinning of the cortex is associated with reduced cognitive flexibility, decreased decision-making ability, and lower success in executive functions, which are essential for successful functioning in society.

One of the most important roles of the frontal cortex is the process of "synaptic pruning," where excess synapses are eliminated to improve the efficiency of neural networks. In young cannabis users, the process of synaptic pruning can be disrupted, leaving the brain in a state of "neural overload," which impairs focus and concentration. Researchers have found that THC promotes apoptosis or programmed death of microglia - the brain's immune system cells, which are crucial for maintaining a healthy neural environment. Damage to microglia due to THC further complicates synaptic pruning, which can have long-term consequences on adolescents' mental health.

Genetic predispositions and potential psychiatric disorders

Besides its impact on the frontal cortex, research has shown that THC may increase the risk of developing psychiatric disorders in young people, especially those with genetic predispositions. A study conducted on mice with a genetic predisposition to schizophrenia showed that exposure to THC causes changes in the structure and function of microglia, leading to greater difficulties in social behavior and memory. These findings confirm that early contact with THC can have long-term effects on the development of neurological and psychiatric symptoms in young users.

Long-term consequences of increasingly potent cannabis products

Changes in legislation in North America have enabled the legalization of cannabis in many states, leading to the emergence of products with high THC content. Today, the average concentration of THC in commercially available products exceeds 20%, while concentrates are often multiple times stronger, reaching up to 76%. This trend exposes young users to more potent psychoactive effects, which can lead to serious long-term consequences, including reduced learning abilities, impaired memory, and decreased motivation, known as amotivational syndrome.

One of the key issues with cannabis use among youth is the decreased perception of the harmfulness of this drug, which often leads to increased frequency of use among adolescents. In the context of public health, it becomes crucial to raise awareness about the consequences and warn young people about the possible harmful effects before cannabis use becomes a habit with serious consequences for their cognitive and social development.

Considering that the adolescent brain is particularly sensitive to psychoactive substances, further research is needed to clarify the relationship between high levels of THC and potential long-term disorders. Such knowledge is essential for creating public health measures that will protect young generations from the risks associated with cannabis use during sensitive developmental stages.

Source: Université de Montréal